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This webinar is free for members and students with a $10 charge made for non- RACI members.
Registrations close at COB, Monday 12 June. Owing to webinar setup activities, later registration applications cannot be accepted.
Recent developments in RNA R&D and manufacturing in NSW
Director, RNA Institute UNSW
Towards distributed manufacture of nanomedicines
CEO Micropore Technologies (UK)
In mid-2022, I gave a webinar for the RACI NSW Pharmaceutical Science group on the plans from both the NSW Government and other governments around the country on establishing onshore manufacturing capabilities in RNA therapeutics, including mRNA vaccine project.
In the 12 months since I gave this presentation, the plans both here in NSW and across the country have moved considerably and the first GMP manufacturing facilities (yes – that is a plural) for RNA products will be online within the next 1-2 years. Here in NSW the tender has been completed for the operation of a pilot-scale GMP RNA production facility to be built on land provided by Macquarie University and the detailed plans for that facilities are being finalised as we speak.
Meanwhile in the RNA developmental space, we seen a number of large scale mRNA project and program initiated including one focused on domestically produced animal vaccine that could then become one of the first, if not the first animal mRNA vaccine in the world. These and other key recent developments in the NSW RNA “ecosystem” will be covered in this talk.
Prof Thordarson is Director of the UNSW RNA Institute which is a science, therapeutics and translational facility driving cross-disciplinary approaches to global challenges in RNA chemistry, biology and medicine. As well, Prof Thordarson is President of the RACI.
As nanomedicines move from the urgency of mRNA vaccines, to minimise the impact of the Covid-19 pandemic, to other exciting nucleotide therapies two significant issues need to be addressed before nanomedicines become truly mainstream therapies; tissue targeting and robust scalability from discovery to manufacture.
This presentation will address the importance of resolving the latter issue as a means of imparting high levels of control, in a formulation agnostic manner, to allow scale-appropriate optimisation of formulations for therapeutic outcomes with no compromises. Micropore Technologies’ established approach to development and manufacture of a variety of nanoparticles will be discussed. A novel whole-process approach, unlocking a route to distributed manufacturing, will be described.
Dai graduated in Chemistry and Physiology, has an MBA, and is a Fellow of the UK’s Royal Society of Chemistry. Dai’s career has been spent in chemistry and biology related businesses. He has been Awarded the Commercial Development & Marketing Association (USA) Golden C Award for professional excellence in commercial development. As a past Chairman of the UK Chemical Industry Association’s Responsible Care Board, a consistent theme has been to achieve more with less while increasing shareholder value. In Micropore Technologies Dai has found a real opportunity to continue to deliver against this theme.
Dai has been CEO of Micropore since 2009 and has led the development of the transition of a lab-based technology to a growing global business offering improved product performance and manufacturing economics to product formulators. He is excited to lead the adoption of this proven technology to enable robust manufacture of complex drug delivery systems and particularly LNPs, liposomes and bioresorbable microspheres.
This webinar is essential viewing for medicinal research scientists in the academic and private sectors as well as manufacturing, QA, laboratory and regulatory personnel in established therapeutic goods organisations.
For any queries on registration, please contact the NSW Branch coordinator, Hannah McCarthy, phone 0401 221 835, email [email protected].
RACI Pharmaceutical Science Group (NSW)